3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	activation mechanism	652498	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	arrangement of two metal ions, a phosphate ion, and amino acid residues in the catalytic site is identical to that of PS/Tpases	665427	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	comparison of kinetic properties of different transmembrane and cytosolic isozymes	650430	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	conformation of active site is favorable for phosphotyrosine binding. Interaction of D115 and R13 to stabilize the conformation of the active cavity. A41 and G45 form a noncharged surface around the active cavity, which is surrounded by a flexible wall made of the loop region from F40 to T48	665402	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	for both alkyl and aryl substrates, including the activated substrate 4-nitrophenyl phosphate with its particularly good leaving group, general acid catalysis in PTPs is highly efficient and fully neutralizes the leaving group in the transition state. Mutating the conserved aspartic acid to glutamine causes the expected reductions in rate of several orders of magnitude and loss of the basic limb in pH-rate profiles, kinetic isotope effects, general acid catalysis mechanism, overview	-, 749953	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	H148 acts as a general acid catalyst, D115 assists the protonation of the leaving group of a substrate, and D76 and D112 are involved in binding of magnesium ions	664363	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site	664310	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	mechanism	650928, 652000, 94997, 95002	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	mechanism of the dephosphorylation catalysed by MptpA	714454	
3.1.3.48	[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate	mechanism, features required for substrate	652017