2.5.1.56	phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate	-	-	
2.5.1.56	phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate	mechanism, essential role for divalent metal ion as an electrophilic catalyst that activates the N-acetylmannosamine carbonyl prior to the addition of phosphoenolpyruvate	659498