2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate ordered-sequential bi bi mechanism -, 638745 2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate reaction mechanism and residues involved in substrate specificity and product chain lengt determination, overview 674562 2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate the condensation of isopentenyl diphosphate to (2E,6E)-farnesyl diphosphate by GGPPS is a bi-substrate/biproduct (bi-bi) reaction, where the two products are geranylgeranyl diphosphate and diphosphate, which is cleaved from (2E,6E)-farnesyl diphosphate. The inhibitory pattern observed by geranylgeranyl diphosphate indicates a compulsory ordered mechanism for isopentenyl diphosphate and (2E,6E)-farnesyl diphosphate binding the enzyme from Choristoneura fumiferana 738380