2.4.99.20 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate reaction 1 b 724210 2.4.99.20 NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide overall reaction. The multifunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming nicotinic acid-adenine dinucleotide phosphate, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes 724210 2.4.99.20 NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide reaction 1a 724210