1.13.11.15 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde - - 1.13.11.15 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde mechanism, substrate chelates the metal ion asymmetrically at sites trans to two imidazole ligands 655872 1.13.11.15 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde substrate binding occurs in a four-step process, transient intermediates and mechanism 654735