1.1.1.B47 4-hydroxybutanoate + NADP+ = succinate semialdehyde + NADPH + H+ - - 1.1.1.B47 4-hydroxybutanoate + NADP+ = succinate semialdehyde + NADPH + H+ the enzyme performs an acid/base catalytic mechanism involving Lys170 as the general acid and a conserved active-site water molecule 737745