5.1.99.7 7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate - - 5.1.99.7 7,8-dihydroneopterin 3'-triphosphate = 7,8-dihydromonapterin 3'-triphosphate reaction mechanism of the epimerase, overview. The reaction can be initiated by protonation of N-5 followed by deprotonation at the acidic C-19 of dihydroneopterin- or dihydromonapterin-type substrates. Epimerization at C-2 might result from reversal of the cleavage reaction without stereochemical control -, 5109