4.1.3.1 isocitrate = succinate + glyoxylate - - 4.1.3.1 isocitrate = succinate + glyoxylate common mechanism for catalysis with succinate: (1) an unfavorable prebinding isomerization of the active site Cys191-His193 pair to the thiolate-imidazolium form, a process that is favored in D2O, and (2) the transfer of a proton from succinate or 3-NP to Cys191 -, 727045 4.1.3.1 isocitrate = succinate + glyoxylate kinetic mechanism is the same in microgravity and in standard g controls 650574