3.5.3.1 L-arginine + H2O = L-ornithine + urea thermodynamic data 172124 3.5.3.1 L-arginine + H2O = L-ornithine + urea also hydrolyses alpha-N-substituted L-arginines and canavanine 654333 3.5.3.1 L-arginine + H2O = L-ornithine + urea substrate binding structure 654593 3.5.3.1 L-arginine + H2O = L-ornithine + urea hydrolysis via a metall-activated hydroxide mechanism, substrate binding structure 654717 3.5.3.1 L-arginine + H2O = L-ornithine + urea Asn130 and Ser137 are involved in substrate binding and catalysis 654949 3.5.3.1 L-arginine + H2O = L-ornithine + urea H141 serves as an acid/base catalyst, deprotonating the metal-bridging water molecule to generate the metal-bridging hydroxide nucleophile, and by protonating the amino group of the product to facilitate its departure 667319 3.5.3.1 L-arginine + H2O = L-ornithine + urea H141 as general acid to protonate the leaving amino group of L-ornithine during catalysis 670673