3.4.17.23 angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine - - 3.4.17.23 angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine a transmembrane glycoprotein with an extracellular catalytic domain. ACE2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates 678102 3.4.17.23 angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine ACE2 catalytic efficiency is 400-fold higher with angiotensin II (1–8) as a substrate than with angiotensin I (1–10). ACE2 also efficiently hydrolyzes des-Arg9-bradykinin, but it does not hydrolyze bradykinin 659172