2.6.1.16 L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate analysis of two catalytic mechanism variants (with neutral Cys1NH2 as the activating base or with His71 as the activating base) by molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) computational methods, detailed overview. Results shows that the most likely catalytic mechanism is determined to involve a neutral Cys1NH2 group acting as the base that activates the Cys1 thiol 760122 2.6.1.16 L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate rapid equilibrium random mechanism 639918