1.14.99.20 phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O enzyme has two distinct functions: vitamin K epoxidation and gamma-glutamyl carboxylation 438308, 438309 1.14.99.20 phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O enzyme linked to the vitamin K dependent carboxylation system 438301, 438302 1.14.99.20 phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O K218 is the essential base that deprotonates AH2 to initiate he reaction 672089 1.14.99.20 phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state 438310 1.14.99.20 phylloquinone + reduced acceptor + O2 = 2,3-epoxyphylloquinone + acceptor + H2O vitamin K-dependent carboxylase activity and vitamin K epoxidase activity are properties of the same protein 438307