6.3.1.20	ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate	overall reaction	
6.3.1.20	ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate	LplA structures are determined: LplA/lipoyl-AMP binary complex and LplA/octyl-5'-AMP/apoH-protein ternary complex. These structures represent a post-lipoate adenylation stage and a pre-lipoate transfer stage, respectively. Three large scale conformational changes in the Escherichia coli LplA structure upon completion of the lipoate adenylation reaction are found, which enable LplA to accommodate apoprotein for the second reaction	
6.3.1.20	ATP + (R)-lipoate = lipoyl-AMP + diphosphate	(1a)	
6.3.1.20	lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP	(1b)