2.3.1.286	phosphoprotein	-	739439	
2.3.1.286	phosphoprotein	phosphorylation of Thr522 is an important allosteric mechanism to activate SIRT1 in response to stress. While non-phosphorylation of this residue leads to formation of less-active oligomers, phosphorylation helps to maintain the monomeric status of SIRT1, resulting in increased activity	730947