3.4.21.27	glycoprotein	the enzyme bears five N-glycosylation consensus sites per monomer	732897	
3.4.21.27	proteolytic modification	factor XI is activated to factor XIa by site-specific cleavage of zymogen factor XI by thrombin, factor XIIa, or autoactivation	683756	
3.4.21.27	proteolytic modification	factor XI is activated to factor XIIa at 37°C, a conformational transition accompanies conversion of factor XI to factor XIa that conceals the Apple 3 domain zymogen factor XI platelet binding site and exposes the factor XIa platelet binding site within the catalytic domain possibly comprising residues Cys527-Cys542	683160	
3.4.21.27	proteolytic modification	FXI activation proceeds through an intermediate with one activated subunit, limited digestion by incubating with FXIIa or thrombin	683682	
3.4.21.27	proteolytic modification	the enzyme shows activation by autolysis involving residues of the autolysis loops, overview	683157	
3.4.21.27	proteolytic modification	the zymogen FXI is activated by proteolytic cleavage to FXIa	684078	
3.4.21.27	proteolytic modification	the zymogen is activated by proteolytic cleavage	683167	
3.4.21.27	side-chain modification	glycoprotein, 11% carbohydrate	36534