Homo sapiens - 2275, 641741, 653885, 661666, 661682, 661735, 662186, 674638, 703285, 703865, 716189 Homo sapiens bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 694815 Homo sapiens bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, splice variant hGNE2 692536 Homo sapiens gene GNE 703912 Homo sapiens isoform 2 673693 Homo sapiens isoform 3 673693 Homo sapiens mutations in patients with hereditary inclusion body myopathy: G135V/R246W (GNE/GNE domain mutation), UDP-N-acetylglucosamine 2-epimerase activity is 38% of wild-type, N-acetylmannosamine kinase activity is 72% of wild-type. V216A/A631V (GNE/MNK domain mutation), UDP-N-acetylglucosamine 2-epimerase activity is 48% of wild-type, N-acetylmannosamine kinase activity is 63% of wild-type. M712T/M712T (MNK/MNK domain mutation), UDP-N-acetylglucosamine 2-epimerase activity is 83% of wild-type, N-acetylmannosamine kinase activity is 55% of wild-type 661840 Homo sapiens three different isozymes, hGNE1, hGNE2, and hGNE3, from the two splice variants including exon A1, The N-terminus of hGNE2 is prolonged by 31 additional amino acids. The lack of exon 2 in the cDNA encoding for hGNE3 leads to loss of the first 55 amino acids of hGNE1 702507 Kocuria varians - 2272 Methanocaldococcus jannaschii - 728782, 749249