3.5.4.10 drug development the enzyme is a potential target for antineoplastic intervention, design of IMPCH inhibitors, overview 687546 3.5.4.10 drug development the enzyme is an important drug target 756701 3.5.4.10 medicine determination of differentially expressed genes in HT-29 cells, both after short treatment with methotrexate and after the resistance to methotrexate has been established. Enzyme as well as survivin and inosine monophosphate dehydrogenase type II are upregulated 668561