3.4.21.113	drug development	binding mode of 2-O-(4-O-galloylgalloyl)-1,3,4-tri-O-galloyl-beta-D-glucose can be used as a scaffold for anti-HCV for the further reconstruction and design of new protease inhibitors	685513	
3.4.21.113	drug development	nonpeptide inhibitors of NS3-SP from Chinese herbal medicine Rhodiola kirilowii may serve as potential candidate anti-hepatitis C virus agents. Cell viability and secreted alkaline phosphatase (SEAP) activity assays with the nonpeptide inhibitors of NS3-SP reveal little if any toxicity	684506	
3.4.21.113	medicine	NS3 protease domain is essential for the process of viral RNA replication and, given its electrostatic contribution to RNA binding, it may also assist in packaging of the viral RNA	687647