3.1.3.75 medicine may have implications for the diagnosis of hypophosphatasia and treatment of bone mineralization abnormalities such as osteomalacia and pathological soft-tissue ossification, a process clinically significant in atheroscleosis and heart failure 654549 3.1.3.75 medicine PHOSPHO1 plays a role in the initiation of matrix mineralization 680993 3.1.3.75 medicine role in the early stages of matrix mineralization 678951