2.4.1.274	medicine	B4GALT5 expression is upregulated in porcine reproductive and respiratory syndrome virus (PRRSV) infected porcine alveolar macrophage. The PRRSV proliferation is slightly inhibited by overexpression of B4GALT5. B4GALT5 and PRRSV protein GP5 colocalize in Golgi membrane. mRNA transcription, including inflammatory cytokines IFN-alpha, IL-6, IL-18, IL-1beta, TNF-alpha and some cell surface glycosylated proteins involved in antigen presentation (MHC-I/II), cell adhesion and migration (chemokine MCP-1 and receptor CCR2; LFA-1, ICAM-1) are upregulated in B4GALT5 overexpressing PRRSV infected cells	759227	
2.4.1.274	medicine	B4GALT5 gene/protein expression is specifically increased in human colorectal cancer tumors, with a concomitant increase in its enzymatic activity, and product lactosylceramide, and increased dihydrosphingolipid metabolites. Inhibition of glycosphingolipid synthesis by the synthetic ceramide analog, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, concurrently inhibits colorectal cancer cell proliferation, as well as B4GALT5 mass and several glycosphingolipid levels	755974	
2.4.1.274	medicine	the amounts of Lac-Cer synthesized by isoform beta4GalT5 correlate with the tumorigenic potentials of malignantly transformed cells	736198