2.3.1.251	medicine	PagP is not required for the initial colonization of the mouse respiratory tract by Bordetella bronchiseptica, but is required for persistence of the organism within this organ	-, 734707	
2.3.1.251	synthesis	deacylated lipid A, deacylated and palmitoylated lipid A, and palmitoylated lipid A species are generated in Escherichia coli cells heterologously expressing salmonellae lipid A 3-O-deacylase PagL and/or PagP, and then purified by sequential thin-layer chromatography. The purified lipid A species show m/z values that correspond to single lipid A species on mass spectrometry analysis. The modified lipid A species show reduced ability to induce cellular signaling through Toll-like receptor 4	734374