3.7.1.4	medicine	adult-type hypolactasia is characterized by a fall of lactase activity levels to 5 - 10% of birth levels occuring during childhood and adolescence	685892	
3.7.1.4	medicine	adult-type hypolactasia results from the progressive decline of lactase-phlorizin hydrolase activity in enterocytes after weaning, lactase nonpersistence may determine a primary lactose intolerance with reduced diary product consumption, which is possibly related to an increased risk of colon cancer	687838	
3.7.1.4	medicine	hypolactasia seems to be strongly corretated with genotype C/C of the genetic variant C->T-13910 upstream of the lactase-phlorizin hydrolase gene	673123	
3.7.1.4	medicine	rapid genotyping assay for LPH-13910 polymorphism based on real-time PCR, which may assist in differentiating patients with primary hypolactasia from those with secondary hypolactasia and lactose intolerance	673123	
3.7.1.4	molecular biology	98% similarity of the rabbit LPH precursor to PNGH sequence, LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing	671823	
3.7.1.4	molecular biology	cell specificty of LPH gene expression depends upon both positive and negative interactions among elements in the first 2kb of the LPH 5'-flanking region, generally positive activity between -74 and -37 bp, a cell-specific negative region between -210 and -95 bp, and additional elements further toward the 5' terminus that confer a highly cell-specific response in reporter activity, potential binding sites for various intestinal transcription factors, binding of HNF3beta at three sites is relevant to LPH expression	675587	
3.7.1.4	molecular biology	LPH and PNGH enzymes have the same genomic origin, but differ in transcriptional and, possibly, post-translational processing	671823