3.1.3.56	medicine	depletion of the inositol polyphosphate 5-phosphatase PIPP (INPP5J) increases breast cancer cell transformation, but reduces cell migration and invasion. PIPP ablation accelerates oncogene-driven breast cancer tumor growth in vivo, but reduces metastasis by regulating AKT1-dependent tumor cell migration. PIPP mRNA expression is reduced in human ER-negative breast cancers associated with reduced long-term outcome	750220	
3.1.3.56	medicine	genetic variation in INPP5A appears to have a role in susceptibility to arsenic toxicity. A single nucleotide polymorphism in the INPP5A gene (rs1133400) shows a significant gene-environment interaction with water arsenic on skin lesion risk	750219	
3.1.3.56	medicine	in individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, bi-allelic mutations in isoform INPP5K are found. Mutations impair phosphatase activity toward phosphatidylinositol (4,5)-bisphosphate or alter the subcellular localization of INPP5K	749530	
3.1.3.56	medicine	potential target for drugs	646389	
3.1.3.56	molecular biology	At5PTase1 and At5PTase2 genes have nonredundant roles in hydrolyzing inositol second-messenger substrates and regulation of Ins(1,4,5)P3 levels is important during germination and early seedling development	682411