2.3.1.286	medicine	3-((2-methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (ICL-SIRT078) has a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line and an optimised derivative thereof, is a candidate neuroprotective agent in in vivo models of Parkinson's disease	729603	
2.3.1.286	medicine	down-regulation of intratumoral and peritumoral Sirt3 are both associated with poor outcome in hepatocellular carcinoma. Intratumoral Sirt3 is a favorable prognostic predictor in early stage patients	729498	
2.3.1.286	medicine	inhibitors of sirtuin-2 deacetylase are protective in various models of Huntington’s disease by decreasing polyglutamine aggregation, a hallmark of pathology of Huntington’s disease	729674	
2.3.1.286	medicine	the enzyme is a promising drug target in the treatment of age-related diseases, such as neurodegenerative diseases and cancer	729680