5.6.1.5 medicine molecular analysis of this parasite, new means to combat drug resistance in malaria, PSF4 may be a target for the development of new antimalarial drugs that will be effective against chloroquine-resistant parasites 5.6.1.5 medicine the finding that the disassembly of the 26S proteasome is an old-age event could explain the presence of protein deposits containing ubiquitinated proteins and oxidatively modified proteins in nonpathologic aging, as well as in a variety of aging-related neurodegenerative disorders 5.6.1.5 medicine the human orthologue of yeast Rpt3, S6 ATPase, interacts with the oncoprotein gankyrin, gankyrin is commonly overexpressed in hepatocellular cancer cells 5.6.1.5 medicine the enzyme serves as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients