1.3.1.24	diagnostics	antiapoptotic effect of the enzyme in cancers portens strategies for developing novel biomarkers and effective treatment ways for cancer patients	763307	
1.3.1.24	diagnostics	peripheral biomarker for the early diagnosis of Alzheimer's disease	763055	
1.3.1.24	medicine	biliverdin reductase B is a prostate cancer marker	740909	
1.3.1.24	medicine	BVR may represent a novel strategy for the treatment of multiple sclerosis and other oxidative stress-mediated diseases, treatment with BVR ameliorates both clinical and pathological signs of autoimmune encephalomyelitis more efficiently than treatments with traditional antioxidant enzymes	673797	
1.3.1.24	medicine	data gathered to date have identified the potential utility of hBVR in modulating cell signaling and the wide range of functions that are regulated by protein kinases that include growth, differentiation, gene transcription and metabolism, regulation of glucose uptake, induction of HO-1, and cytokine and Toll-like receptor signaling are potential target candidates for hBVR-based therapeutic strategies	701357	
1.3.1.24	medicine	finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions	711965	
1.3.1.24	medicine	hyperbiliverdinaemia, green jaundice, with green plasma and urine may be caused by a genetic defect in the BVR-A gene in conjunction with decompensated liver cirrosis	699950	
1.3.1.24	medicine	Tat-mediated transduction of biliverdin reductase A may provide a potential tool to ameliorate beta-cell deficit in pancreas with type 2 diabetes mellitus	740267	
1.3.1.24	medicine	therapeutic potential of human BVR and human HVR-based peptides by affecting the MAPK signaling pathways, overview	711795	
1.3.1.24	additional information	BVR regualtes cellular levels of biliverdin, a potent gene regulator and determinant factor for dorsal axis development in Xenopus larva	676353	
1.3.1.24	additional information	interacts with the insulin receptor kinase domain, key factor in the MAPK pathway and the PI3K pathway as well as regulating PKC isoforms that link the two pathways, plays a role in the mechanism of insulin resistance	676353	
1.3.1.24	additional information	potential function in propagation of signals relayed through protein kinase C, binds to protein kinase C betaII, increases its phosphorylation, and is a substrate for the kinase, increases PMA-dependent c-fos activation and protein kinase C translocation to the membrane	674899	
1.3.1.24	additional information	potential role in the insulin signaling pathway, BVR is both a substrate for insulin receptor tyrosine kinase activity and a kinase for serine phosphorylation of insulin receptor substrate 1	666747	
1.3.1.24	additional information	regulates oxidative response and HO-1 expression	676353	
1.3.1.24	pharmacology	critical role for biliverdin reductase A in protecting against lipid accumulation and oxidative stress in hepatocytes which may serve as a future therapeutic target for non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH)	762673	
1.3.1.24	pharmacology	transduced fusion protein Tat-biliverdin reductase A (Tat-BLVRA) markedly inhibits cell death, DNA fragmentation, and generation of ROS. Transduced Tat-BLVRA inhibits the apoptosis and mitogen activated protein kinase (MAPK) signaling pathway and it passes through the blood-brain barrier (BBB) and significantly prevents hippocampal cell death in an ischemic model. Tat-BLVRA provides a possibility as a therapeutic molecule for ischemia	763156