6.3.2.11 ATP + L-His + beta-Ala the concentration of histidine in muscle and plasma is high relative to its Km with muscle carnosine synthase, whereas beta-alanine exists in low concentration in muscle and has a higher Km with muscle carnosine synthase, which indicates that it is the availability of beta-alanine that is limiting to the synthesis of carnosine in skeletal muscle 6.3.2.11 ATP + L-histidine + beta-alanine - 6.3.2.11 L-histidine + beta-alanine + ATP -