4.2.1.18 (S)-3-hydroxy-3-methylglutaryl-CoA catalyzes fifth step in the leucine degradation pathway 4.2.1.18 (S)-3-hydroxy-3-methylglutaryl-CoA fifth step in the leucine degradation pathway 4.2.1.18 (S)-3-hydroxy-3-methylglutaryl-CoA isovalerate as sole carbon and energy source in Acinetobacter is metabolized via isovaleryl-CoA, oxidative (S)-leucine degradation pathway 4.2.1.18 (S)-3-Hydroxy-3-methylglutaryl-CoA penultimate step in Leu catabolism 4.2.1.18 (S)-3-Hydroxy-3-methylglutaryl-CoA enzyme is involved in Leu degradation 4.2.1.18 trans-3-methylglutaconyl-CoA + H2O -