3.4.24.B28 major histocompatibility complex class I polypeptide-related sequence B + H2O ectodomain shedding 3.4.24.B28 additional information in contrast other ADAM15 isoforms ADAM15i3 interacts preferentially with Hck and Lyn containing proteins 3.4.24.B28 nephrocystin + H2O - 3.4.24.B28 nephrocystin + H2O strong co-precipitation of nephrocystin from cell lysates is specific to ADAM15 isoforms i4, i5, and i6