3.4.24.7	Collagen + H2O	-	
3.4.24.7	collagen I + H2O	degradation	
3.4.24.7	collagen III + H2O	degradation	
3.4.24.7	Collagen type I + H2O	-	
3.4.24.7	Collagen type III + H2O	-	
3.4.24.7	Collagen type III + H2O	ability of MMP-1 to unwind triple-helical collagen	
3.4.24.7	additional information	ligation of keratinocyte alpha2beta1 integrin by type 1 collagen induces expression of matrix metalloproteinase-1. The MMP-1 activity is required for the alpha2beta1 integrin-dependent migration of primary keratinocytes across collagenous matrices. MMP-1 binds to the I domain of the alpha2 intergrin subunit	
3.4.24.7	additional information	matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt and neuronal death through a non-proteolytic mechanism. MMP-1 might contribute to the neuronal damage which occurs in association with degenerative and inflammatpry conditions characterized by elevated levels of this proteinase	
3.4.24.7	additional information	MMP-1 is involved in intestinal re-epithelization in vivo and is upregulated by cytokines relevant in wound repair	
3.4.24.7	additional information	enzyme regulation on expression and protein levels, overview