3.4.24.3 Collagen + H2O - 3.4.24.3 Collagen + H2O degradation of helical regions of native collagen to small fragments, preferential cleavage: -Gly in the sequence Pro-Xaa-Gly-Pro 3.4.24.3 Collagen + H2O clostridial collagenase A is effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns, CCA aggravates the systemic inflammatory response in rats with partial-thickness burns, inflammatory reactions such as fever, leukocytosis or leukocytopenia and increased CRP levels in sera are often observed in a significant proportion of burn victims treated with CCA ointment, although synchronous wound swab cultures show no signs of infection, overview 3.4.24.3 Collagen + H2O proteolytic degradation, the enzyme helps the skin to heal after burns and dermal ulcers, but can cause allergic reactions, overview 3.4.24.3 Collagen + H2O type II collagenase ColH acts inside of the collagen triple helix molecule 3.4.24.3 Collagen type I + H2O - 3.4.24.3 Collagen type I + H2O type I collagenase ColG acts on the N-terminal level of the triple helix of collagen 3.4.24.3 collagen type II + H2O - 3.4.24.3 Collagen type III + H2O - 3.4.24.3 Gelatin + H2O -