3.4.22.1	amyloid beta peptide + H2O	cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview	
3.4.22.1	amyloid beta precursor protein + H2O	cathepsin B selectively cleaves the wild-type beta-secretase site but not the rare Swedish mutant beta-secretase site	
3.4.22.1	amyloid-beta + H2O	-	
3.4.22.1	caspase 1 precursor + H2O	-	
3.4.22.1	Collagen + H2O	-	
3.4.22.1	Collagen IV + H2O	-	
3.4.22.1	Collagen IV + H2O	collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview	
3.4.22.1	Gelatin + H2O	-	
3.4.22.1	Laminin + H2O	laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview	
3.4.22.1	additional information	enzyme is involved in myoblast-myoblast fusion