3.4.21.73	alpha6 integrin + H2O	alpha6 integrin is present on prostate carcinoma escaping the gland via nerves. Urokinase-dependent cleavage of the laminin binding domain from the prostate tumor cell surface	
3.4.21.73	additional information	active enzyme promotes tumor progression, activation of enzyme appears as a key step in tumor progression	
3.4.21.73	additional information	enzyme protein is consistently elevated in the hyperproliferative hair follicle keratinocyte, and inhibiton of enzyme decreases hair follicle keratinocyte proliferation	
3.4.21.73	additional information	enzyme released by alveolar epithelial cells alters alveolar epithelial repair in vitro by modulating the underlying fibrin matrix	
3.4.21.73	additional information	structure and interdomain contacts of the N-terminal domain of the enzyme with the uPA receptor, binding structure, mechanisms responsible for the cellular responses induced by uPA binding, overview	
3.4.21.73	additional information	the enzyme is a serine protease involved in tissue remodeling and cell migration, the active form of uPA is bound to its high affinity receptor on the cell surface, where specific inhibitors modulate its enzymatic activity, such inhibitors also regulate the cell surface levels of uPA by triggering the internalization of the uPA-receptor-inhibitor complex via endocytosis, overview, the C-terminus of the N-terminal region contains a sequence that interacts with alphaVbeta3 integrin and is relevant for cell migration, overview	
3.4.21.73	additional information	the enzyme is involved in colorectal cancer invasion and metastasis	
3.4.21.73	additional information	the enzyme plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis	
3.4.21.73	additional information	the enzyme supports liver repair independent of its cellular receptor uPAR, overview	
3.4.21.73	additional information	the enzyme-plasminogen activator inhibitor-1 complex in intenalized by endocytosis via binding of membrane-bound receptors, overview