2.7.7.41 CTP + 1-stearoyl-2-arachidonoyl-sn-phosphatidic acid - 2.7.7.41 CTP + 1-stearoyl-2-linoleoyl-sn-phosphatidic acid - 2.7.7.41 CTP + phosphatidate - 2.7.7.41 CTP + phosphatidate the enzyme is involved in the regulation of phospholipid metabolism 2.7.7.41 CTP + phosphatidate mammalian enzymes show similar efficacy for CTP and dCTP, however CTP is the preferred substrate in vivo, since dCDP-diacylglycerol is not detectable in mammalian tissues. In Escherichia coli equivalent amounts of CDP-diacylglycerol and dCDP-diacylglycerol are detected. Arabinofuranosylcytosine is also found to be incorporated into lipid in mammalian cells, suggesting that it is a substrate for the enzyme 2.7.7.41 CTP + phosphatidate enzyme plays a central role in phospholipid biosynthesis 2.7.7.41 CTP + phosphatidate the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids 2.7.7.41 CTP + phosphatidate the enzyme is required for the regeneration of the signalling molecule phosphatidylinositol-4,5-diphosphate from phosphatidic acid. A photoreceptor cell-specific isoform is a key regulator of phototransduction, a G-protein-coupled signalling cascade mediated by phospholipase C 2.7.7.41 CTP + phosphatidate the enzyme plays a regulatory role in phototransduction by ensuring an adequate supply of phosphatidylinositol-4,5-diphosphate 2.7.7.41 CTP + phosphatidate regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity