2.4.2.28 5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate trypanocidal substrate analogue 2.4.2.28 5'-deoxy-5'-(hydroxyethylthio)adenosine + phosphate preincubation of cells with the substrate lead to 22-37% inhibition of spermidine synthesis from ornithine and 2-7fold increased cytosolic levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine, and up to 8fold increased cytosolic level of 5'-methyladenosine 2.4.2.28 5'-deoxy-5'-methylthioadenosine + phosphate salvage reaction 2.4.2.28 5'-deoxy-5'-methylthioadenosine + phosphate involved in cardiac purine breakdown during ischemia 2.4.2.28 5'-deoxy-5'-methylthioadenosine + phosphate substrate is a by-product of polyamine biosynthesis, which is essential for cell growth and proliferation 2.4.2.28 5'-deoxy-5'-methylthioadenosine + phosphate - 2.4.2.28 5'-methylthioadenosine + phosphate - 2.4.2.28 5'-methylthioadenosine + phosphate important for the salvage of adenine and methionine 2.4.2.28 5'-methylthioadenosine + phosphate an antiproliferative effect on stimulated human lymphocytes and virally transformed mouse fibroblasts 2.4.2.28 5'-methylthioadenosine + phosphate involved in salvage of adenine and methionine from 5'-methylthioadenosine