2.4.2.19 beta-nicotinate D-ribonucleotide + diphosphate + CO2 - 2.4.2.19 additional information key enzyme of NAD+ biosynthesis 2.4.2.19 additional information enzyme of the kynurenine pathway 2.4.2.19 additional information key enzyme in NAD+ biosynthesis, also plays an important role in ensuring nicotinic acid available for the synthesis of defensive pyridine alkaloids 2.4.2.19 additional information intermediary enzyme in the de novo NAD biosynthetic pathway 2.4.2.19 additional information the recruitment of this gene for growth on phthalate gives Burkholderia cepacia an advantage over other phthalate-degrading bacteria in the environment 2.4.2.19 additional information key enzyme in catabolism of quinolinate. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders 2.4.2.19 additional information essential enzyme for the de novo biosynthesis of NAD+ 2.4.2.19 additional information enzyme is probably involved in the regulation of nicotine biosynthesis 2.4.2.19 phosphoribosyl diphosphate + quinolinic acid -