2.1.1.361	3 S-adenosyl-L-methionine + a [histone H4]-L-lysine20	-	
2.1.1.361	additional information	enzyme binding to the nucleosome protects it from degradation during the cell cycle. Full length enzyme has 3.8% of its histone methyltransferase activity on nucleosomes containing the H2A/E61A/ E64A/D90A/E92A mutations compared to wild type nucleosomes	
2.1.1.361	additional information	the enzyme is completely inactive toward histone H4 with a K20L mutation	
2.1.1.361	additional information	the proteolytic degradation of the enzyme is controlled by the SCFSlimb ligase complex	
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-L-lysine20	-	
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-L-lysine20	highly specific substrate	
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-N6,N6-dimethyl-L-lysine20	-	
2.1.1.361	S-adenosyl-L-methionine + a [histone H4]-N6-methyl-L-lysine20	-	
2.1.1.361	S-adenosyl-L-methionine + [p53]-L-lysine382	-