2.1.1.227 additional information the 2'-O-methyltransferase TlyA from Mycobacterium tuberculosis methylates both nucleotide C1409 of 16S rRNA and C1920 of 23S rRNA, EC 2.1.1.226 2.1.1.227 S-adenosyl-L-methionine + cytidine1409 in 16S rRNA -