1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism 1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O the bifunctional reductase/saccharopine dehydrogenase contains the first two enzyme of lysine catabolism, is concertedly regulated by metabolic and stress-associated signals. The level of the bifunctional enzyme is strongly enhanced by abscisic acid, jasmonate, and sugar starvation, whereas excess sugars and nitrogen starvation reduce its level 1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O - 1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O reaction of the SDH domain 1.5.1.9 saccharopine + NAD+ + H2O -