1.14.13.128	1,3,7-trimethylxanthine + O2 + NAD(P)H + H+	i.e. caffeine	
1.14.13.128	1,3,7-trimethylxanthine + O2 + NADPH + H+	i.e. caffeine	
1.14.13.128	7-methylxanthine + O2 + NAD(P)H + H+	-	
1.14.13.128	7-methylxanthine + O2 + NAD(P)H + H+	part of the caffeine degradation pathway in Pseudomonas putida	
1.14.13.128	7-methylxanthine + O2 + NADH + H+	-	
1.14.13.128	7-methylxanthine + O2 + NADH + H+	specific substrate	
1.14.13.128	7-methylxanthine + O2 + NADH + H+	the N7-demethylation reaction absolutely requires a unique, tightly bound protein complex composed of NdmC, NdmD, and NdmE. NdmE functions as a noncatalytic subunit that serves a structural role in the complexation of the oxygenase (NdmC) and Rieske domains (NdmD)	
1.14.13.128	7-methylxanthine + O2 + NADH + H+	immediate degradation via the NdmCDE complex	
1.14.13.128	caffeine + O2 + NADH + H+	-	
1.14.13.128	additional information	the metabolite is 1,3-dimethylxanthine, i.e. theophylline, is produced by the demethylation in the 7th position of the purine ring, mainly in fungi, overview