4.99.1.4 sirohydrochlorin + Fe2+ - 4.99.1.4 sirohydrochlorin + Fe2+ CysG, siroheme biosynthesis 4.99.1.4 sirohydrochlorin + Fe2+ Met8p catalyzes ferrochelation during the biosynthesis of siroheme 4.99.1.4 sirohydrochlorin + Fe2+ Met8p catalyzes the final two steps in the biosynthesis of siroheme involving a beta-NAD+-dependent dehydrogenation of precorrin-2 to generate sirohydrochlorin followed by ferrochelation to yield siroheme 4.99.1.4 sirohydrochlorin + Fe2+ SirB is responsible for the final step in siroheme synthesis