4.4.1.22	5,6,7,8-tetrahydromethanopterin + formaldehyde	-	
4.4.1.22	S-(hydroxymethyl)glutathione	the enzyme accelerates the spontaneous reaction in which the adduct of formaldehyde and glutathione is formed, i.e. the substrate for EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase, in the formaldehyde-detoxification pathway