3.5.4.4 2'-deoxyadenosine + H2O - 3.5.4.4 2'-deoxyadenosine + H2O the enzyme plays an important role in the immune system 3.5.4.4 5'-methylthioadenosine + H2O - 3.5.4.4 5'-methylthioadenosine + H2O adenosine deaminase has a secondary function in recycling methylthiopurines from the polyamine biosynthetic pathway 3.5.4.4 adenosine + H2O - 3.5.4.4 adenosine + H2O isozyme ADA2 is important in lymphocyte activation, and may be active in sites of inflammation and during hypoxia and in areas of tumor growth with elevated adenosine levels and acidic pH, overview 3.5.4.4 adenosine + H2O key enzyme in controlling intra- and extracellular adenosine levels 3.5.4.4 adenosine + H2O the enzyme activity is correlated with the content in malonaldehyde in nasal polyps and nasal mucosa, overview 3.5.4.4 adenosine + H2O the enzyme expression and activity is suppressed in normal pregnancy, but not in woman with recurrent spontaneous abortion 3.5.4.4 adenosine + H2O the enzyme is crucial for purine metabolism and normal immune competence