3.4.24.71 amyloid beta peptide + H2O - 3.4.24.71 amyloid-beta peptide + H2O - 3.4.24.71 amyloid-beta peptide + H2O degradation 3.4.24.71 angiotensin I + H2O - 3.4.24.71 angiotensin-I + H2O degradation, no activity with angiotensin-II 3.4.24.71 big endothelin + H2O - 3.4.24.71 big endothelin + H2O activation 3.4.24.71 big endothelin + H2O ECE-1 is a membrane-bound metalloprotease responsible for production of vasoactive endothelin-1 from inactive big ET-1 3.4.24.71 big endothelin + H2O PKCepsilon regulates the expression of ECE-1 in the brain 3.4.24.71 Big endothelin 1 + H2O key enzyme in endothelin production, generates potent vasoconstrictor endothelin from its inactive precursor