3.4.23.36 bacterial lipoprotein + H2O - 3.4.23.36 bacterial lipoprotein + H2O cleavage of the signal peptide, the enzyme is essential for lipoprotein biosynthesis 3.4.23.36 FKBP8 + H2O i.e. SCSLVLEHQPDNIK 3.4.23.36 heme oxygenase 1 + H2O - 3.4.23.36 invariant chain CD74 of the major histocompatibility II complex + H2O - 3.4.23.36 additional information processing of the lipid-modified prolipoproteins 3.4.23.36 additional information signal peptidases are integral components of the secretory pathway 3.4.23.36 additional information lipoprotein processing by LspA is required for virulence of the organism and acts as virulence determinant of tuberculosis 3.4.23.36 additional information essential component of lipoprotein processing 3.4.23.36 additional information processing of prolipoproteins seems to be conserved among different bacterial species, and requires type II signal peptidase mediated cleavage of the N-terminal signal peptide to form the mature lipoprotein. Deletion of Sp0928 prevented processing of Streptococcus pneumoniae prolipoproteins to mature lipoproteins