3.4.22.B75	additional information	a module of two PxVxL HP1 interaction motifs on enzyme SENP7 mediates association with HP1, molecular basis for the interaction between SENP7 and HP1, the capacity for SENP7 to interact with HP1 in cells and its capacity to de-SUMOylate SUMO1-HP1 are independent	
3.4.22.B75	additional information	the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1	
3.4.22.B75	poly-SUMO-2 + H2O	the C-terminal catalytic domain of SENP7 efficiently depolymerized poly-SUMO-2 chains but has undetectable activity against poly-SUMO-1 chains	
3.4.22.B75	SUMO1-HP1 + H2O	deSUMOylation	
3.4.22.B75	SUMO2/3ylated HP1alpha + H2O	HP1alpha localizes at the pericentric heterochromatin, importance of SUMOylation in directing HP1alpha’s subnuclear localization, SUMO deconjugation by enzyme SENP7	
3.4.22.B75	SUMOylated c-Myc + H2O	-	
3.4.22.B75	SUMOylated HP1alpha + H2O	SUMO deconjugation by enzyme SENP7	
3.4.22.B75	SUMOylated KRAB-associated protein 1 + H2O	enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1