3.4.21.9	additional information	enterokinase light chain is a serine protease that recognizes Asp-Asp-Asp-Asp-Lys, D4K, sequence and cleaves the C-terminal peptide bond of the lysine residue	
3.4.21.9	protein C inhibitor + H2O	-	
3.4.21.9	Trypsinogen + H2O	-	
3.4.21.9	Trypsinogen + H2O	initiation of digestive enzyme activation by converting trypsinogen into trypsin	
3.4.21.9	Trypsinogen + H2O	initiates activation of pancreatic hydrolases by cleaving and activating trypsinogen	
3.4.21.9	Trypsinogen + H2O	enterokinase deficiency is a distinct clinical entity characterized by diarrhea, failure to thrive, hypoproteinemia, and edema. Acquired enterokinase deficiency may occur in some diffuse small bowel diseases. Steatorhea of cellac sprue may be due partly to the fact that deficiency of secretin and cholecystokinin may interfere with the action of enterokinase	
3.4.21.9	Trypsinogen + H2O	the enzyme plays a key role in initiating the proteolytic digestion cascade in duodenum by converting trypsinogen to trypsin	
3.4.21.9	Trypsinogen + H2O	physiological activator of trypsinogen	
3.4.21.9	Trypsinogen + H2O	rapid activation of trypsinogen in pancreatic juice. The enzyme has a key permissive role in protein digestion and plays an essential part in the zymogen mechanism that protects the pancreas from self-destruction	
3.4.21.9	trypsinogen + H2O	cleavage after the sequence DDDDK