3.4.21.27	factor IX + H2O	activation of Factor IX in the intrinsic coagulation cascade	
3.4.21.27	factor IX + H2O	-	
3.4.21.27	factor IX + H2O	factor XIa has a role in the intrinsic pathway of coagulation, and plays a significant role in venous thrombosis	
3.4.21.27	factor IX + H2O	factor XIa is essential for the optimal activation of FIX	
3.4.21.27	factor IX + H2O	two forms of activated factor XI are generated during coagulation, and each half of a factor XIa dimer behaves as an independent enzyme with respect to factor IX	
3.4.21.27	factor IX + H2O	after binding to factor XIa, factor IX undergoes a single cleavage to form the intermediate factor IXalpha. FIXalpha then rebinds to the A3 domain to undergo a second cleavage, generating factor IXalphabeta	
3.4.21.27	factor V + H2O	fXIa cleaves COOH-terminal to R306, possibly at the fXa/plasmin cleavage site R348	
3.4.21.27	factor VIII + H2O	fXIa initially cleaves at R740 and R372 in the heavy chain and also makes several A3 cleavages most notably at R1652 and R1721	
3.4.21.27	pro-HGF + H2O	the enzyme may regulate processes that involve the HGF/c-Met pathway, such as tissue repair and angiogenesis	
3.4.21.27	prochemerin + H2O	-