3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O - 3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O substrate for epoxide hydrolase activity 3.3.2.6 (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O substrate for the epoxide hydrolase reaction, in addition LTA4H shows a peptidase activity 3.3.2.6 leukotriene A4 + H2O - 3.3.2.6 leukotriene A4 + H2O one of the physiologically important processes in the arachidonic acid biosynthetic pathway, leukotriene B4 is a proinflammatory mediator which stimulates adhesion of circulating neutrophils to vascular endothelium and directs their migration towards sites of inflammation 3.3.2.6 leukotriene A4 + H2O central enzyme in leukotriene B4 formation, it is likely to be involved in transcellular leukotriene formation 3.3.2.6 leukotriene A4 + H2O biosynthesis of leukotriene B4 3.3.2.6 leukotriene A4 + H2O leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid 3.3.2.6 leukotriene A4 + H2O leukotriene A4 hydrolase catalyzes the final step in the synthesis of leukotriene B4, a potent chemoattractant and proinflammatory eicosanoid. LTB4 functions as a macrophage chemoattractant in the zebrafish, injection into the hindbrain ventricle of wild-type arvae induces rapid recruitment of macrophages 3.3.2.6 additional information possible proteolytic function of the enzyme may be limited to the extracellular space