2.7.4.3 2 ADP the enzyme plays a key role in maintaining the balance of ADP and ATP in cell 2.7.4.3 ADP + ADP facilitates transfer of high-energy phosphorylss and signal communication between mitochondria and actomyosin in cardiac muscle 2.7.4.3 ADP + ADP provides unique buffering role against rapid concentration changes of any component of the adenylate pool 2.7.4.3 ADP + ADP facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems 2.7.4.3 ADP + ADP involved in energy metabolism 2.7.4.3 ADP + TDP Escherichia coli adenylate kinase is able to synthesize TTP, but the activity is too low to explain the high rate of TTP accumulation uring amino acid starvation of cells 2.7.4.3 ATP + AMP - 2.7.4.3 ATP + AMP the enzyme is involved in regulating concentration of ATP in cells 2.7.4.3 ATP + AMP the enzyme plays a key role in maintaining the balance of ADP and ATP in cell 2.7.4.3 additional information adenylate kinase activity Is required for Mre11/Rad50-mediated DNA tethering